- Important Dates
- Conference:Nov. 26-28, 2021
- Submission:Extended to Oct. 28, 2021
- 20-40 days after the submission
- 7-10 days after the final edition
- Contact Information
- Email: email@example.com
- Cell Phone: 0086-18101720867
- Telephone: 021-51098086
- WeChat: 18101720867
The information about the Keynote Speakers of MEDLIFE2021 is as follows, which will be updated regularly.
Biography: Associate Professor Xin Ge is working in the Department of ICU, Wuxi 9th Affiliated Hospital of Soochow University. He received a B.S. degree from Dalian Medical University and joined in Central hospital of Jinzhou in 2005. He received an M.S. degree in surgery in Jinzhou Medical University in 2015. In 2016 he became vice-director of neurosurgery and director of NICU in Central hospital of Jinzhou. In the same year, he admitted to the PLA General Hospital for his Ph.D. in neurosurgery under professor Xinguang Yu. In 2018 he admitted to Haerbin Medical University for his Ph.D. in ICU under professor Mingyan Zhao. He was appointed director of ICU in 2020 in Wuxi 9th Affiliated Hospital of Soochow University. In the past 5 years, he has published 6 SCI papers with the highest IF of 8.32 and 4 Chinese core journal papers. He presided over a special project of Precision Medicine of Wuxi Municipal Health Commission, participated in the project of National Brain Prevention Commission and a research and development program of the Ministry of Science and Technology during the 13th Five-Year Plan period.
Topic: Stress-Induced Phosphoprotein 1 Restrains Spinal Cord Ischemia-Reperfusion Injury by Regulating Nf-Κb Signaling
Abstract: This study aims to investigate the effects of stress-induced phosphoprotein 1 (STIP1) on spinal cord ischemia-reperfusion injury (SCII). SCII was induced by clamping the abdominal aorta for 1 h and reperfusion for 24 h in rats. Immunoblotting and immunohistochemical staining results showed that STIP1 rapidly increased and then decreased in the spinal cord of rats with SCII treatment. Lentivirus containing STIP1 coding sequence was intrathecally injected into rats to overexpress STIP1. Neurological function score, HE staining, immunofluorescent staining, and western blot results revealed that STIP1 overexpression alleviated SCII-induced motor dysfunction of hind limbs, neuronal loss and inflammation in the spinal cord, and inhibited activity of nuclear factor kappa B (NF-κB) signaling in rats. Moreover, STIP1 co-located with Iba-1, a marker of activated microglia. Mouse microglia BV2 underwent oxygen and glucose deprivation (OGD) for 6 h, and reperfusion for 24 h. STIP1 ameliorated OGD-induced inflammation and activation of NF-κB signaling in BV2 cells. In addition, STIP1 resulted in the decrease of heat shock protein family A member 8 (HSPA8), an increase of inhibitor of NF-κB (IκB)β levels, and IκBβ bound to HSPA8 in BV2 cells. We hypothesized that STIP1 elevated IκBβ levels by occupying HSPA8, and then deactivated NF-κB signaling. In summary, STIP1 alleviated ischemia-reperfusion induced neuronal injury and inflammation in the spinal cord of rats and mouse microglial cells by deactivating NF-κB signaling. These findings may provide novel insights for clinical diagnosis and treatment for spinal cord injury.
Biography: Dr. Lei Zhang received his PhD on medical science from Uppsala University, Sweden. In 2017, he moved back to China and established his research group on brain tumor microenvironment in Shaanxi Normal University. In 2019, he was appointed as director of China-Sweden International Joint Research Center for Brain Diseases. Dr. Zhang is an expert in tumor microenvironment with special focus on glioblastoma vascular abnormality and blood-brain barrier alterations. In recent 5 years, he was principle investigator of two NSFC research projects, one Key R&D Program of Shaanxi Province. He has been elected as editor board member of “Traditional Medicine Research”, and as board member of Shaanxi Anti-Cancer Association and Shaanxi Society of Biochemistry and Molecular Biology. He has published several research articles as first author or last author in leading journals including Neuro-Oncology, JCI Insight, Science Signaling, Cellular Oncology et al.
Topic: Key Molecular Alterations in Endothelial Cells in Human Glioblastoma Uncovered by Single-Cell RNA Sequencing
Abstract: Glioblastoma is the most aggressive type of brain tumor with poor therapeutic response and prognosis. Passage of systemically delivered pharmacological agents into the brain is largely blocked by the blood-brain-barrier (BBB), an organotypic specialization of brain endothelial cells (ECs). Tumor vessels in GBM are abnormal and generally more permeable, but the heterogeneity of BBB breakdown in different parts of the tumor vascular tree and in vessels surrounding the tumor is largely unknown. Here, through single-cell RNA sequencing (sc-RNAseq) of freshly isolated ECs from human glioblastoma and paired non-malignant tissues, we have constructed a molecular atlas of human brain ECs providing unprecedented molecular insight into the heterogeneity of the human BBB and its molecular alteration in glioblastoma. We identified 5 distinct EC phenotypes, resembling different phenotypes and associating with distinct anatomical location within the tumor. This unique resource will provide key information for designing rational therapeutic regimens and optimizing drug delivery.